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Ingredient Evidence Review

Caffeine (slow-release microencapsulated)

Caffeine anhydrous (sustained-release microcapsule)

Last updated 2026-05-19 · 3 primary citations

Mechanism

Caffeine blocks adenosine, the molecule that builds up over your waking hours and makes you sleepy. Standard caffeine spikes and falls off in 4 hours. The slow-release form keeps you alert across a full 8–12 hour shift without the second-hour jitter or the fifth-hour crash. Paired with L-theanine, the result is steady focus rather than wired-and-tired.

Why we use it

Sleep-medicine guidelines support caffeine for shift workers because it works. The problem is the delivery curve — immediate-release leaves you crashing mid-shift. The slow-release form is engineered specifically for sustained vigilance.

How we dose it

Hericea uses 100 mg per serving (per On-Shift stick pack). The clinical trial range that anchors this dose is 100–200 mg/day.

100 mg of caffeine — about a single cup of coffee — but encapsulated in a slow-release coating so it dribbles into the bloodstream over 4+ hours instead of spiking once and crashing.

Quality & sourcing

Slow-release microencapsulated caffeine anhydrous; sustained release ≥4hr. NSF Annex C permitted.

SR microencapsulation tech; not immediate-release powder.

Cautions

  • consult physicianAvoid if pregnant, on stimulants, or with arrhythmias.
  • informationalAvoid within 6hr of intended sleep.

Primary literature

Haskell CF et al. (2008)

Biol Psychol
PubMed

RCT

Caffeine + L-theanine improved attention and reaction time more than caffeine alone in healthy adults.

The foundational evidence for pairing caffeine with theanine — exactly what the AM stick does for sustained shift alertness.

PMID 18006208

Ker K et al. (2010)

Cochrane Database Syst Rev
PubMed

Cochrane meta-analysis

Caffeine reduced shift-work errors and improved vigilance vs placebo across pooled trials.

Highest tier of evidence (Cochrane review) for the exact use case — preventing errors on shift.

PMID 20464731

McLellan TM et al. (2016)

Neurosci Biobehav Rev
PubMed

Review

Reviewed military and operational evidence: caffeine reliably restores cognitive performance during sleep deprivation.

Most relevant comparator group — operational shift workers, not coffee-drinkers.

PMID 27612937