Clear-headed
through menopause.

Hericium erinaceus

Lion's Mane is the only food known to nudge your brain into making more of its own repair signal — a protein called nerve growth factor that keeps neurons maintained and connected. Its active compounds switch that signal on; the dedicated Erinacine-A row next to it covers the second, complementary one. As estrogen falls and the fog sets in, that maintenance signal is exactly what wobbles.

Hericium erinaceus HeG-strain (CNS-penetrant fraction)

Lion's Mane mushroom has two families of brain-active compounds. Hericenones (in the row above) work on one growth signal. Erinacines work on a different, complementary signal called BDNF — and erinacine A is special because it crosses directly into the brain (most compounds can't). Together they cover both major brain-growth pathways the perimenopausal brain needs.

Crocus sativus (stigma extract)

Saffron's two active compounds (crocin and safranal) gently support the brain's mood chemistry and help steady the stress response — the same systems that get noisy when estrogen drops. In perimenopausal women specifically, standardized saffron has been studied for low mood and for the frequency of hot flushes.

Cytidine 5'-diphosphocholine

Your brain uses a chemical called acetylcholine to form and recall memories. Citicoline is the raw material your brain needs to make it. As we age, supply drops; this delivers it directly. Cognizin® is the specific patented form used in the clinical trials — not generic citicoline.

Phosphatidylserine (sunflower-derived)

Phosphatidylserine is a fat that sits in the outer wall of every brain cell. It's what lets signals move smoothly between cells. Stress and aging deplete it. Restoring it has been shown to support memory and to blunt the cortisol spike that stress causes — which is especially relevant in perimenopause when cortisol regulation gets noisier.

Re-esterified triglyceride DHA + EPA

DHA is the main building block of your brain's cell walls — roughly 30% of your brain is literally made of DHA. Your body can't make it, you have to eat it. EPA is its anti-inflammatory partner. Together they keep brain cells flexible and reduce the kind of low-grade inflammation perimenopause amplifies.

6S-5-methyltetrahydrofolate glucosamine salt

Folate is the raw material your body uses to keep nerve cells healthy and to recycle a toxic byproduct called homocysteine. When homocysteine builds up, it accelerates brain shrinkage. The famous VITACOG trial showed that giving the right form of folate, B12, and B6 together slowed brain shrinkage by 30–50% in older adults with high homocysteine.

Methylcobalamin

B12 maintains the protective insulation around nerve fibers and works as a pair with folate to keep brain-aging biomarkers in check. B12 deficiency is one of the most common — and most missed — causes of brain fog and fatigue in adults over 50.

Pyridoxal-5-phosphate

B6 is a cofactor in over 140 reactions in your body, including making the mood and motivation chemicals dopamine and serotonin. It's the third leg of the homocysteine-clearance system the VITACOG trial showed protects the aging brain.

Ganoderma lucidum

Reishi is the most studied calming mushroom in traditional medicine. Two compound families do the work: long-chain sugars (called beta-glucans) help with sleep onset, and bitter compounds (called triterpenes) help quiet the stress-hormone response. You need both extractions to get both effects.

Magnesium L-threonate

Most magnesium supplements never make it past your stomach into your brain. Magtein® uses a special carrier (L-threonate) that gets magnesium across the blood-brain barrier. Brain magnesium is required for the kind of deep, restorative sleep that gets thinner with age — and a 2025 clinical trial showed this form measurably 'reverses' a few years of brain aging.

Glycine (amino acid)

Falling asleep depends on your body cooling down by about a degree. Glycine triggers that cool-down by opening small blood vessels in your hands and feet, releasing heat. It also calms the brain's arousal signals. The result: shorter time to fall asleep, deeper slow-wave sleep, less daytime fatigue the next day.

N-acetyl-L-cysteine

Your body's most important internal antioxidant is called glutathione, and the rate-limiting step in making it is having enough of an amino acid called cysteine. NAC is the cleanest, most studied way to deliver that cysteine. Pairs with glycine (the other half of the glutathione recipe) which sits in the same packet.

Urolithin A (ellagitannin-derived gut metabolite)

Inside every cell are tiny power plants called mitochondria. They wear out with age. Urolithin A is a compound your body normally makes from pomegranate and berries — but only if you have the right gut bacteria, which most people don't. It triggers your cells to recycle their worn-out power plants. The clinical trials so far have shown this translates into measurable improvements in muscle endurance.

L-ergothioneine

Ergothioneine is an antioxidant that's unusual in two ways: humans can't make it (so we have to eat it), and we have a dedicated transporter that pulls it into tissues — especially the brain. It accumulates in mitochondria (the cell's power plants) where it's particularly useful. Falling blood levels are an early warning sign of cognitive decline.

Curcuma longa rhizome extract (SLCP complex)

Curcumin is the active compound in turmeric. It calms the kind of low-grade inflammation that drives both brain fog and joint stiffness. The hard part is getting it into your bloodstream — most curcumin supplements don't deliver any meaningful amount. Longvida® is engineered specifically to fix that absorption problem.

Lithium orotate (the orotate salt form)

Lithium is a naturally occurring mineral your body absorbs from drinking water (in trace amounts) and certain foods. At microdoses, it supports the brain's wiring at the level of cell-to-cell connections — and a major 2025 *Nature* paper showed that running low on lithium is one of the earliest detectable changes in the brain before Alzheimer's. We use the orotate salt because it delivers lithium without the amyloid-binding problem the prescription form has.