Ingredient Library
Every ingredient.
One canonical page each.
Reused across every Hericea formula that contains the ingredient. Each page is one consolidated evidence review with the mechanism, the clinical-trial dose range, every PubMed-cited paper we screened, the branded form we use, and the lot-level certificate of analysis.
Lion's Mane fruiting body dual extract
Hericium erinaceus
Lion's Mane is the only food known to nudge your brain into making more of its own repair signal — a protein called nerve growth factor that keeps neurons maintained and connected. Its active compounds switch that signal on; the dedicated Erinacine-A row next to it covers the second, complementary one. As estrogen falls and the fog sets in, that maintenance signal is exactly what wobbles.
4 papers · AM · 1,500 mg
Erinacine-A mycelium concentrate
Hericium erinaceus HeG-strain (CNS-penetrant fraction)
Lion's Mane mushroom has two families of brain-active compounds. Hericenones (in the row above) work on one growth signal. Erinacines work on a different, complementary signal called BDNF — and erinacine A is special because it crosses directly into the brain (most compounds can't). Together they cover both major brain-growth pathways the perimenopausal brain needs.
3 papers · AM · 200 mg
Saffron
Crocus sativus (stigma extract)
Saffron's two active compounds (crocin and safranal) gently support the brain's mood chemistry and help steady the stress response — the same systems that get noisy when estrogen drops. In perimenopausal women specifically, standardized saffron has been studied for low mood and for the frequency of hot flushes.
3 papers · AM · 56 mg
Citicoline
Cytidine 5'-diphosphocholine
Your brain uses a chemical called acetylcholine to form and recall memories. Citicoline is the raw material your brain needs to make it. As we age, supply drops; this delivers it directly. Cognizin® is the specific patented form used in the clinical trials — not generic citicoline.
4 papers · AM · 500 mg
Phosphatidylserine
Phosphatidylserine (sunflower-derived)
Phosphatidylserine is a fat that sits in the outer wall of every brain cell. It's what lets signals move smoothly between cells. Stress and aging deplete it. Restoring it has been shown to support memory and to blunt the cortisol spike that stress causes — which is especially relevant in perimenopause when cortisol regulation gets noisier.
5 papers · AM · 300 mg
Omega-3 rTG (microencapsulated)
Re-esterified triglyceride DHA + EPA
DHA is the main building block of your brain's cell walls — roughly 30% of your brain is literally made of DHA. Your body can't make it, you have to eat it. EPA is its anti-inflammatory partner. Together they keep brain cells flexible and reduce the kind of low-grade inflammation perimenopause amplifies.
4 papers · AM · 1,600 mg
5-MTHF (methylated folate)
6S-5-methyltetrahydrofolate glucosamine salt
Folate is the raw material your body uses to keep nerve cells healthy and to recycle a toxic byproduct called homocysteine. When homocysteine builds up, it accelerates brain shrinkage. The famous VITACOG trial showed that giving the right form of folate, B12, and B6 together slowed brain shrinkage by 30–50% in older adults with high homocysteine.
3 papers · AM · 800 mcg
Methyl-B12
Methylcobalamin
B12 maintains the protective insulation around nerve fibers and works as a pair with folate to keep brain-aging biomarkers in check. B12 deficiency is one of the most common — and most missed — causes of brain fog and fatigue in adults over 50.
2 papers · AM · 1,000 mcg
P-5-P (active B6)
Pyridoxal-5-phosphate
B6 is a cofactor in over 140 reactions in your body, including making the mood and motivation chemicals dopamine and serotonin. It's the third leg of the homocysteine-clearance system the VITACOG trial showed protects the aging brain.
2 papers · AM · 25 mg
Reishi fruiting body dual extract
Ganoderma lucidum
Reishi is the most studied calming mushroom in traditional medicine. Two compound families do the work: long-chain sugars (called beta-glucans) help with sleep onset, and bitter compounds (called triterpenes) help quiet the stress-hormone response. You need both extractions to get both effects.
3 papers · PM · 1,500 mg
Magnesium L-threonate
Magnesium L-threonate
Most magnesium supplements never make it past your stomach into your brain. Magtein® uses a special carrier (L-threonate) that gets magnesium across the blood-brain barrier. Brain magnesium is required for the kind of deep, restorative sleep that gets thinner with age — and a 2025 clinical trial showed this form measurably 'reverses' a few years of brain aging.
4 papers · PM · 2,000 mg
Glycine
Glycine (amino acid)
Falling asleep depends on your body cooling down by about a degree. Glycine triggers that cool-down by opening small blood vessels in your hands and feet, releasing heat. It also calms the brain's arousal signals. The result: shorter time to fall asleep, deeper slow-wave sleep, less daytime fatigue the next day.
3 papers · PM · 3,000 mg
N-acetylcysteine (NAC)
N-acetyl-L-cysteine
Your body's most important internal antioxidant is called glutathione, and the rate-limiting step in making it is having enough of an amino acid called cysteine. NAC is the cleanest, most studied way to deliver that cysteine. Pairs with glycine (the other half of the glutathione recipe) which sits in the same packet.
2 papers · PM · 1,200 mg
Urolithin A
Urolithin A (ellagitannin-derived gut metabolite)
Inside every cell are tiny power plants called mitochondria. They wear out with age. Urolithin A is a compound your body normally makes from pomegranate and berries — but only if you have the right gut bacteria, which most people don't. It triggers your cells to recycle their worn-out power plants. The clinical trials so far have shown this translates into measurable improvements in muscle endurance.
5 papers · PM · 1,000 mg
Ergothioneine
L-ergothioneine
Ergothioneine is an antioxidant that's unusual in two ways: humans can't make it (so we have to eat it), and we have a dedicated transporter that pulls it into tissues — especially the brain. It accumulates in mitochondria (the cell's power plants) where it's particularly useful. Falling blood levels are an early warning sign of cognitive decline.
3 papers · PM · 25 mg
Curcumin
Curcuma longa rhizome extract (SLCP complex)
Curcumin is the active compound in turmeric. It calms the kind of low-grade inflammation that drives both brain fog and joint stiffness. The hard part is getting it into your bloodstream — most curcumin supplements don't deliver any meaningful amount. Longvida® is engineered specifically to fix that absorption problem.
3 papers · PM · 400 mg
Lithium orotate (microdose)
Lithium orotate (the orotate salt form)
Lithium is a naturally occurring mineral your body absorbs from drinking water (in trace amounts) and certain foods. At microdoses, it supports the brain's wiring at the level of cell-to-cell connections — and a major 2025 *Nature* paper showed that running low on lithium is one of the earliest detectable changes in the brain before Alzheimer's. We use the orotate salt because it delivers lithium without the amyloid-binding problem the prescription form has.
4 papers · PM · 1 mg elemental
PQQ (Dihydrogen-PQQ)
Pyrroloquinoline quinone (reduced form)
PQQ is a small molecule that signals your cells to grow new mitochondria — the cellular power plants that decline with age. The most recent human trial showed it specifically increased brain oxygen levels and improved memory testing in adults already experiencing cognitive decline.
3 papers · AM · 20 mg
Sulforaphane
Sulforaphane (broccoli seed extract)
Sulforaphane is the compound that gives broccoli sprouts their reputation. It switches on your body's main antioxidant defense gene (called Nrf2) — flipping a master switch that produces dozens of protective enzymes at once. Especially relevant for brain inflammation and the cellular damage that accumulates with age.
4 papers · PM · 25 mg
PQQ (PM dose)
Pyrroloquinoline quinone (reduced form, PM)
Same PQQ as the morning row, taken again in the evening. Mitochondrial growth happens around the clock; cell-energy decline is one of the deepest changes in the 55+ brain. We dose PQQ on both ends of the day to sustain the signal.
3 papers · PM · 20 mg
Reishi fruiting body dual extract
Ganoderma lucidum
Reishi's bitter triterpene compounds help steady the body's stress-hormone (cortisol) response, and its long-chain sugars support immune balance. In the morning that translates to a calmer baseline under sustained pressure — not sedation.
3 papers · AM · 1,500 mg
Cordyceps militaris fruiting body
Cordyceps militaris (orchid mushroom)
Cordyceps contains a compound called cordycepin that helps your cells — including brain cells — make more energy, partly by blocking the same chemical signal that makes you feel tired. It comes from the actual mushroom (the fruiting body), the only form that carries cordycepin in real amounts.
3 papers · AM · 1,500 mg
Sceletium tortuosum (Zembrin®)
Sceletium tortuosum (kanna)
Zembrin® is a standardized extract of the South African plant kanna. It takes the edge off acute stress quickly — brain-imaging studies show it quiets the threat-detection circuitry — but without sedating you. The point is calmer, not slower.
3 papers · AM · 25 mg
L-tyrosine (free form)
L-tyrosine (amino acid)
Tyrosine is an amino acid your brain converts directly into dopamine and norepinephrine — the chemicals behind focus, drive, and stress tolerance. Under heavy mental load you burn through them faster than you make them, and supplemental tyrosine refills the supply.
3 papers · AM · 2,000 mg
KSM-66 Ashwagandha
Withania somnifera (root extract)
KSM-66® is the most clinically studied form of ashwagandha, an adaptogen that helps the body return to baseline after stress. Its most consistent effect across trials is lowering cortisol — the stress hormone — which is why it sits in the evening packet to help a high-output day actually wind down.
3 papers · PM · 600 mg
Caffeine (slow-release microencapsulated)
Caffeine anhydrous (sustained-release microcapsule)
Caffeine blocks adenosine, the molecule that builds up over your waking hours and makes you sleepy. Standard caffeine spikes and falls off in 4 hours. The slow-release form keeps you alert across a full 8–12 hour shift without the second-hour jitter or the fifth-hour crash. Paired with L-theanine, the result is steady focus rather than wired-and-tired.
3 papers · AM · 100 mg
L-theanine
L-theanine (from green tea)
L-theanine is the amino acid in green tea that makes a green-tea caffeine boost feel calm rather than jittery. It produces alpha-wave brain activity (the same pattern as relaxed focus and meditation) and softens caffeine's edge without blunting its alertness benefit.
3 papers · AM · 200 mg
N-acetylcysteine (600mg)
N-acetyl-L-cysteine (reduced dose)
Your body makes its own primary antioxidant called glutathione. The rate-limiting ingredient is cysteine — NAC is the bioavailable form that gets it where it needs to go. Helps the body clear oxidative damage that accumulates faster under sleep deprivation.
2 papers · PM · 600 mg
Honokiol / magnolol (Magnolia 80/20)
Magnolia officinalis bark extract
Honokiol and magnolol act on the same brain target as anti-anxiety medications (the GABA system) — but at a gentle modulating level, not a blunt switch. The result is faster sleep onset and quieter mental chatter at bedtime without the next-morning fog or the tolerance that builds up with pharmaceutical sedatives.
4 papers · PM · 250 mg
Melatonin (microdose)
Melatonin (N-acetyl-5-methoxytryptamine)
Melatonin is the hormone your brain releases at night to tell your body it's time to sleep. Shift workers need to override that signal — sleeping during the day, when their natural production is suppressed. A microdose mimics the natural release pattern; a megadose blunts the body's own clock.
3 papers · PM · 0.3 mg
Gastrodin (Gastrodia elata)
Gastrodia elata (tian ma)
Gastrodin acts on multiple brain systems at once — it gently engages the same calming receptor system as magnolia (GABA), supports the production of growth factors that protect brain cells, and reduces inflammation in the brain. Preclinical work in sleep-deprivation models shows it helps recover from circadian disruption.
3 papers · PM · 600 mg
Creatine monohydrate
Creatine monohydrate
Creatine is most famous as a muscle supplement. What's less well-known is that the brain uses the same energy system, and head-impact biology depletes brain creatine fast. Supplementing rebuilds the brain's energy buffer — the body of evidence specifically for head-impact populations is now solid enough that the US Department of Defense issued an information paper on it in 2025.
4 papers · AM · 5,000 mg
Tart cherry concentrate
Prunus cerasus (Montmorency)
Tart cherries contain naturally occurring melatonin (in nutritional, not supplemental, amounts) plus anthocyanins — the deep red pigment compounds that reduce muscle inflammation. The combination supports both sides of recovery at once: sleep architecture and muscle-soreness reduction.
4 papers · PM · 480 mg