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Hericea
HericeaResearchIngredientsLion's Mane fruiting body dual extract

Ingredient Evidence Review

Lion's Mane fruiting body dual extract

Hericium erinaceus

Last updated 2026-05-19 · 4 primary citations

Mechanism

Lion's Mane is the only food known to nudge your brain into making more of its own repair signal — a protein called nerve growth factor that keeps neurons maintained and connected. Its active compounds switch that signal on; the dedicated Erinacine-A row next to it covers the second, complementary one. As estrogen falls and the fog sets in, that maintenance signal is exactly what wobbles.

Why we use it

Lion's Mane is paired with the dedicated Erinacine-A concentrate so the AM stick covers both fungal neurotrophic axes (NGF and BDNF) — what no commodity Lion's Mane achieves.

How we dose it

Hericea uses 1,500 mg per serving (per AM stick pack). The clinical trial range that anchors this dose is 1,000–3,000 mg/day.

1,500 mg of HPLC-verified fruiting-body dual extract. Hericenones C+D quantified per lot — never the cheaper mycelium-on-grain commodity.

Quality & sourcing

≥30% beta-glucan; ≥0.5% hericenones (C+D); alpha-glucan ≤5%; HPLC-CAD verified per lot.

Fruiting body dual extract (NOT mycelium-on-grain). Nammex RealLionsMane® or Eversio equivalent.

Cautions

  • informational1–5% minority-negative response (transient anxiety, low mood, or itching). Covered by the 60-day refund window.

Primary literature

Mori K et al. (2009)

Phytother Res
PubMed

RCT · 30 people · 16 weeks · Adults aged 50–80 with MCI

Hericium erinaceus 3 g/day (250 mg × 4 × 3) improved cognitive function on the revised Hasegawa Dementia Scale at 8, 12, and 16 weeks vs placebo.

PMID 18844328

Docherty S et al. (2023)

Nutrients
Source

RCT pilot · 41 people

Acute Lion's Mane supplementation improved speed of performance on a cognitive task in young adults; chronic 28-day use reduced subjective stress.

DOI 10.3390/nu15224842

Cordaro M et al. (2025)

Front Pharmacol
PubMed

Systematic review (preclinical)

Systematic review — erinacines and Hericium compounds elevate NGF and BDNF in preclinical neurodegeneration models; consistent neurotrophic signal.

PMID 40626304

Roda E et al. (2023)

Int J Mol Sci
PubMed

Translational review

Hericium erinaceus in neurodegenerative diseases — from bench to bedside review of mechanism and clinical evidence.

PMID 37233262