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Hericea
HericeaResearchIngredientsN-acetylcysteine (NAC)

Ingredient Evidence Review

N-acetylcysteine (NAC)

N-acetyl-L-cysteine

Last updated 2026-05-19 · 2 primary citations

Mechanism

Your body's most important internal antioxidant is called glutathione, and the rate-limiting step in making it is having enough of an amino acid called cysteine. NAC is the cleanest, most studied way to deliver that cysteine. Pairs with glycine (the other half of the glutathione recipe) which sits in the same packet.

Why we use it

Perimenopause is an oxidative-stress moment — hormones drop, inflammation runs higher, and your body's antioxidant defenses fall behind. NAC restocks the most important antioxidant your body makes. We pair it with glycine because both are needed to build glutathione; one without the other does much less.

How we dose it

Hericea uses 1,200 mg per serving (per PM packet). The clinical trial range that anchors this dose is 600–1,800 mg/day.

1.2 grams — the standard antioxidant-support dose. Higher doses (around 7 grams) have been studied for cognitive reversal in older adults; we are deliberately not making that claim at this dose.

Quality & sourcing

USP pharma-grade; free-form powder; ≥99% purity.

Standard USP NAC. No proprietary brand.

Cautions

  • consult physicianConsult physician if on nitrate medications or anticoagulants.

Primary literature

Kumar P et al. (2021)

Clin Transl Med
PubMed

Open-label pilot · 8 people · 24 weeks

Glycine + NAC together (GlyNAC) in older adults improved antioxidant levels, mitochondrial function, inflammation markers, and cognition.

This trial validated the pairing principle in our PM packet — glycine and NAC work as a system. Note: Hericea uses a lower dose than this trial and does not claim cognitive reversal.

PMID 33783984

Sekhar RV (Baylor) (2021)

Aging (Albany NY)
Source

Open-label clinical

Established that age-related decline in glutathione is driven by limited supply of its building blocks — glycine and cysteine — and that adding both reverses the decline.

The mechanism paper behind the pairing. Confirms why a glycine-and-NAC packet is a stronger antioxidant strategy than either ingredient alone.